Label free sensing
We are extending the capabilities of localized surface plasmon resonance (LSPR) sensing towards the detection and measurement of single molecules, using combination of experiments and simulations.
Microwell arrays for single molecule studies
By isolating molecules or nanoparticles in femtoliter-sized reactors we can detect and measure activities on thousands of individual molecules in parallel.
Optical characterization of novel nanomaterials
We use spectroscopic and imaging techniques to characterize nanomaterials including exotic core-shell particles and segmented nanowires. (Collaborations with Yacaman and Monton groups.)
Sub-diffraction limited imaging
By using point-spread function fitting, we can pinpoint the locations of molecules. We use this technique to characterize nanoparticle bioconjugates and to study the spatial arrangement of membrane proteins.
Nanoparticles for radiation therapy
We are developing antibody-functionalized gold nanoparticles for targeted, localized radiation therapy enhancement, through a combination of simulations, phantom studies, and in vitro studies. (Collaboration with UT Health Science Center San Antonio.)